Wednesday, February 26, 2014

Calculating Toxicity of Household Items

First, here's a copy of the 6 weeks test.

Your rationales for the questions you missed are due tomorrow.

6 Weeks test for rationales

Rationales include:

1. Justification for the one right answer.
2. Justifications for why all other answers are incorrect.

Your homework is to bring one household chemical (small quantity in a baggie or container).

You need to research the MSDS (Material Safety Data Sheet) for this material and find:

1. Toxic Substances as defined by OSHA
2. LD50 for an adult rat.
3. Calculate LD50 for yourself.

Here's the procedure for calculating LD50:
http://teacherweb.com/CA/UniversityCityHighSchool/MrsTaraHowell/CalculateforLD50lab.pdf 

Follow all three steps to convert to grams. 

Here's an example:

I Googled "Mr. Clean Bathroom Spray" and was taken to the Procter and Gamble site which provided the MSDS
http://teacherweb.com/CA/UniversityCityHighSchool/MrsTaraHowell/CalculateforLD50lab.pdf


I took this information from the website:

SECTION III - COMPOSITION AND INGREDIENTS
Hazardous Ingredients as defined by OSHA, 29 CFR 1910.1200 and/or WHMIS under the HPA:
Chemical Name Common Name CAS No. Composition Range LD50
2-Hydroxy-1,2,3- Propanetricarboxylic Acid Citric Acid 77-92-9 3-7% Oral (rat) > 3 gm/kg
Butoxy Propoxy Propanol Dipropylene Glycol n-Butyl ether 29911-28-2 3-7% Oral (rat) > 3.5 g/kg
N-(3-Cocoamidopropyl)- N,N-dimethyl-N-carboxymethyl betaine Cocamidopropyl Betaine 61789-40-0 1-5% Dermal (rat) > 2g/kg
Since 2 grams is the lowest lethal dose, therefore I will calculate based on this dose:

Step 1: Convert my weight to kg

135 lbs x  1 kg/ 2.205 lbs = 61.22 kg

Step 2:
61.22 kg X 2000mg/kg = 122440 mgLD50

Step 3:
122440mgLD50 x 1mg/1000 g = 122.44 g/person 


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